Vascular calcification, qhov txaus ntshai tsim ntawm calcium deposits hauv kev pheej hmoo ntawm lub plawv nres, yog tsis muaj kev pheej hmoo ntawm lub plawv nres, thiab cov neeg tsim kev noj qab haus huv zoo tib yam, cov lus nug tseem ceeb tshwm sim: tuaj yeemVitamin K2 HmoovRov qab cov txheej txheem tuag no, thiab yog tias yog li, nws tau ntev npaum li cas?
Cov lus teb, txhawb los ntawm lub cev loj hlob ntawm kev tshawb fawb, yog nuanced {{}}}}}} Kev Noj Qab Haus Huv, tab sis muaj peev xwm rov qab los, thiab muaj peev xwm rov qab los, thiab kev hloov pauv ntawm lub hlis, thiab cov ntsiab lus ntawm kev noj qab haus huv, thiab muaj peev xwm rov qab los, thiab kev hloov pauv ntawm lub hlis, thiab cov ntsiab lus ntawm kev noj qab haus huv Pov thawj .
1. Cov Science Qab Vitamin K2 thiab Kev Noj Qab Haus Huv: MGP Kev Txuas
Vitamin K2 lub luag haujlwm hauv kev noj qab haus huv kev noj qab haus huv ntawm nws lub peev xwm los ua kom muaj kev ua kom muaj txiaj ntsig (mgp), muaj zog inhibitor ntawm cal.
Ua kom muaj:MGP yog synthesized nyob rau hauv vascular du cov leeg hlwb {}}-carboxylation, kev tiv thaiv lawv cov ntawv tso tawm hauv phab ntsa plab thiab cov mos mos Cov ntaub so ntswg .
Qhov txaus ntshai ntawm inactivity:Tsis muaj txaus vitamin k2, mgp tseem nyob hauv nws daim ntawv tsis ua haujlwm (DP-Utherosclerosis loj hlob ntawm vitamin thiab muaj cov kab mob ntshav siab thiab muaj cov kab mob siab ua haujlwm, Coronary Attender Calcification, thiab {{5 5 5}}
K2 vs . k1:Thaum vitamin k1 (pom nyob rau hauv zaub ntsuab) yog qhov tseem ceeb rau kev ua kom muaj zog ntawm cov ntshav hauv lub neej kev ua kom muaj zog, tsis zoo li k1, uas tshem sai sai.
Qhov tseem ceeb, cov vitamin K2 ua raws li qhov tseem ceeb "ntawm kev hloov" rau lub cev muaj zog tiv thaiv kev tiv thaiv kev ua rau muaj kev cuam tshuam zoo.
2.}} Ua pov thawj rau Timelines: Ntev npaum li cas rau Vitamin K2 Hmoov kom pom cov teebmeem?
Kev tshawb fawb qhia tau zoo rau kev cuam tshuam ntawm kev noj qab haus huv ntawm lub hli, tab sis tseem ceeb ntxeev, feem ntau yuav tsum tau tsim cov cim, feem ntau yuav tsum tau tsim cov sijhawm ntev dua, txhawb nqa ntxiv,.
a) qeeb zuj zus (3-9 lub hlis)
Chres Mob Kab Mob (CKD) Cov Neeg Mob raum (9 hlis - 270 hnub): Kev kawm Polish polish tau tshaj tawm nyob rau hauv Pum Poline Med Wewn koom nrog 42} {{d), thaum lwm tus tau txais cov vitamin D . Tom qab 9 lub hlis (270 hnub):
* Qhov nce nyob rau hauv cov kev mob ntshav siab ib txwm muaj kev mob siab (CCA-IMT), tau qis dua hauv pawg (}}
* Thaum lub nroog Diam Mob Caltery Qhov qhab nia (CACS)
b) txhim kho arterial stiffness ({0}} xyoo)
Noj qab nyob zoo postmenopausal poj niam (3 xyoos):Daim duab peb-xyoo RCT rau ntawm lub plab txhav muaj kev sib koom tes tau ntsuas ({}}}}}
* Cov pab pawg placebo tau ua rau muaj kev ntsuas me ntsis hauv ob qho tib si ntsuas (1 . 3% thiab 0.22%, ntsig txog).
* Qhov tseem ceeb, cov poj niam nrog cov peev txheej siab dua uas tau txais cov txiaj ntsig zoo tshaj plaws ntawm 3 xyoos, ua kom muaj zog ntawm K2 (mk}
C) Kev cuam tshuam rau Calcorification Remersal: Sib xyaw Ua Tau & Cov Kev Cia
Qhov no yog qhov uas tau dhau los ua cov nyom, tshwj xeeb tshaj yog nyob rau hauv tib neeg nrog tsim cov calcification:
Cov kev tshawb fawb tsiaj qhia qhia kev thim rov qab (6-12 lub lis piam): Ib qho kev kawm khiav nrawm nrawm los ntawm schurgers thiab al {{}}}}}}} {(mk -4) rau 6 lossis 12 lub lis piam:
* Tom qab 6 lub lis piam, ob pab pawg K1 thiab K2% txo tau kwv yees li 37% txo cov kua paug piv txwv {}}
* Tom qab 12 lub lis piam, kev txo qis mus txog 53%.
* Cov ntsiab lus elasticity kuj tseem rov qab 1011. Qhov kev txhawb nqa zoo tshaj plaws tab sis siv cov tshuaj pharapacological deb tshaj li tib neeg txhawb nqa kev pab txhawb
Tib neeg Aortic Valve Calcification (2 xyoo - tsis zoo):Cov avadec thiab cov kev tsis sib tw tau tsom ntsoov rau cov txiv neej laus (}}}}}}}
* Tsis muaj qhov sib txawv ntawm Aortic Valve Calcification Progression tau tsim los ntawm cov pawg {} dose} d tshaj 2 .
Tib neeg cov leeg mob sib txawvThaum lub sijhawm tseem ceeb ntawm cov Danco Danco loj / Related RCT (389 tus neeg koom nrog lub plawv dhia ua ntej
* Cov neeg tuaj koom tau txais k 2+ d Muaj qeeb qeeb Cacs ({}}}}} {{5}.
* Qhov tseeb, hauv cov pawg ntseeg pawg tawm nrog cov hauv paus loj dua lossis sib npaug nrog 400}}}}}} 512.
* Cov xwm txheej kev nyab xeeb (plawv nres, revascularization, tuag) tau qis dua hauv cov txiaj ntsig zoo (1}}}}}}}}}}}}}} Qhov no qhia tau tias cov kab K2 qeeb xwb thiaj li muaj feem ntau hauv cov neeg muaj kev suav nrog cov neeg muaj feem ntau, thiab tuaj yeem txo cov txheej xwm plawv.
3.}} yam cuam tshuam yuav ua li cas ntev ntev ntev li longvitamin k2 hmoov yuav siv mus ua haujlwm
Lub sijhawm ntev rau pom cov txiaj ntsig los ntawm Vitamin K2 ntawm Arterial Kev Noj Qab Haus Huv Tsis Zoo Li Cas.} ob peb qhov tseem ceeb ua si lub luag haujlwm:
Muab thiab daim ntawv (mk -7 yog qhov tseem ceeb):Cov koob tshuaj ntau dua (e {{{0} g}}}}}}} mk {}} mk {}} mk {}} mk {}} mk}, tau los ntawm natto, muaj ntau dua ib nrab-lub neej dua li lwm cov ntaub ntawv (zoo li mk {}}} Kev ua kom ruaj khov, ruaj khov {} Feem ntau cov kev sim siab ib zaug siv Mk -7.
Baseline Vitamin K Txheej Txheem / Tsis Txaus:Cov tib neeg uas muaj qhov tsis txaus ntseeg (HIGCMGP ntau qib) thiab muaj kev hloov pauv ntawm lub hlis (
Lub hauv paus ntawm kev noj qab haus huv ntawm kev noj qab haus huv:Cov uas muaj mob atheroscleroscleroscleroscleroscleros lossis tawv nqaij me me (e {} TSUAS .
Cov-txhawb nrog cov vitamin D:Vitamin D txhawb cov synthesis ntawm MGP, thaum K2 ua haujlwm ing .}}}}}} {} {3}
Underlying kev noj qab haus huv:Cov neeg nyob rau hauv cov kev pheej hmoo siab rau kev ntsuas sai sai (e {} Txawm li cas los xij, CKT,
Cov tshuaj raws li:Vitamin K Antassists (vkas zoo li Warfarin) Ncaj Ncees Vitamular Kev Ua Phem thiab ua kom muaj kev cuam tshuam rau cov neeg mob {}} Cov nyhuv anticoagulants (doocs tshiab (doog) tsis muaj qhov tsis zoo no kev sib cuam tshuam .
4. Yuav ua li cas cov ntaub ntawv pov thawj qhia: Lub sijhawm tiag tiag sijhawm rau cov hom phiaj sib txawv
Raws li kev tshawb fawb tam sim no:
1. Kev txo cov dp-ucmgp (biomarker): Qhov no tuaj yeem tshwm sim hauv KRITE 5] {} Qhov no qhia tau zoo dua MGP ua peev xwm {{{}}
2. qeeb zuj zus ntawm atherosclerosis (e .} pa-}} Cov pa pheej hmoo yog ua rau cov neeg mob ckd {}
3.}} Connecting Arterial Stiffness (E {}}}}}}} {{{7}.
4. maj mam ua kom muaj kev loj hlob (CAC)) xyoo .}} tiav "tshem tawm" lossis thim rov qab ntawm CAC nyob rau hauv lub sijhawm no tsis xwm yeem hais txog tib neeg kev sim siab.
5. Qhov cuam tshuam rau Addanced Hwjchim: Tam Sim No} Kuv tseem ceeb}
6. Tej zaum txo qis hauv cov txheej txheem cardiovascular: kev tuag) nrog cov dej num ntau dua li 2 xyoos, txawm tias tsis muaj koob meej CAC
5.} TSEEM CEEB TE thiab cov lus pom zoo
Vitamin K2 (li mk -7) yog qhov tseem ceeb, tsis yog xaiv:Kev ua siab zoo vascular kev noj qab haus huv yuav tsum tau txaus kom txaus mgp thiab tiv thaiv patological conception. Cov zaub mov noj niaj hnub no yog qhov tsis txaus.
Kev tiv thaiv yog qhov tseem ceeb:Pib K2 ntxiv ua ntej kev tsim cov calcification tseem ceeb rau kev saib xyuas kom meej, hloov pauv ntawm lub neej zoo li lub neej {}}
Reversal siv sijhawm thiab xwm yeem:Thaum biomarker txhim kho tshwm sim tsis pub dhau lub hlis, kev txhawb nqa tseem ceeb tshaj plaws, feem ntau}} xyoo .
Tswj kev cia siab rau cov calcalisfe:Tsis txhob cia siab tias Vitamin K2 kom sai "ntom, tshwj xeeb hauv lub sijhawm tsim nyog tau ua tiav (} {}}}}} {{4 4}}
Synergy nrog vitamin D:Muab kev sib txuas k2 (mk -7}) nrog cov vitamin d3 rau kev txhawb nqa ntawm MGP system (D Txhawb cov synthesis, K2 Enables Thiaj).
Cov Teeb Meem Zoo:Siv cov npe nrov, kev tshawb nrhiav-thim rov qab ntawm mk -7 (zoo li K2Vital®) paub txog kev ruaj ntseg thiab bioavailability {}}
Pab Tswv Yim Kev Pabcuam Kev Noj Qab Haus Huv:Tshwj xeeb yog cov tseem ceeb rau cov tib neeg ntawm anticoagulants (zoo li Warfarin), nrog CKD, lossis lwm yam mob hnyav .
Xaus: ua siab ntev thiab tsis tu ncua rau kev noj qab haus huv ntawm kev noj qab haus huv
Lo lus nug "Ntev Npaum Li CasVitamin K2 HmoovTxhawm rau kom meej arteries? "Tsis muaj ib tug yooj yim standerific cov pov thawj thiab kev txhim kho} (mk}}}}}}}}}}}}}} Protein (MGP) .
Thaum txo qis hauv biomarkers zoo li DP-UCMGP tshwm sim ntawm kev ua kom zoo nkauj, thiab muaj peev xwm txhim kho cov txiaj ntsig zoo nkauj, thiab muaj feem cuam tshuam rau cov txiaj ntsig txhua hnub Cais . Txawm li cas los xij, hloov siab siab tshaj plaws li qub, hauv lub siab ntev ({}} .
Lub tswv yim tshaj lij yog thaum ntxov thiab kev tiv thaiv kev noj qab haus huv, K2} sawv cev rau cov uas muaj kev sib cav sib ceg ntawm cov neeg muaj txhij txhua los txhawb vascular kev noj qab haus huv thoob lub sij hawm ntev, yuav tsum tau ua siab ntev thiab pheej.
Kev xyiv fabnrhiav tau hauv xyoo 2013 yog qhov kev ua haujlwm tsim hluav taws xob-thauj khoom lag luam biotechnology, thiab cov khoom lag luam cog {}}}}} Yog koj xav paub ntau ntxiv txogVitamin K2 Hmoovlos yog txaus siab rau kev yuav nws, koj tuaj yeem xa email raucontact@joywinworld.com. Peb yuav teb rau koj sai li sai tau tom qab peb pom cov lus .